KMID : 0605720210270010067
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Journal of the Korean Society of Biological Therapies in Psychiatry 2021 Volume.27 No. 1 p.67 ~ p.73
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Structural Changes in the Hippocampal Subfields in Early-Onset Mild Cognitive Impairment
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Moon Seok-Woo
Yoo Do-Yen
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Abstract
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Objectives£ºThe aim of this study was to examine the structural change in the hippocampal subfields in early-onset (EO) mild cognitive impairment (MCI) patients associated with the APOE ¥å4 carrier state.
Methods£ºThis study had 50 subjects aged 55-63 years, all of whom were diagnosed with amnestic MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer¡¯s Disease Assessment Packet (CERAD-K). The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer¡¯s disease (AD) converted (ADconv) groups 2 years later. The volumes of hippocampal subfields were measured for all the subjects. The calculations were based on the change of the volumes between the 2-year-interval brain Magnetic resonance image (MRI) scans between MCIcont and ADconv groups according to the Apolipoprotein ¥å4 (APOE ¥å4) carrier state.
Results£ºThere was a significant correlation between APOE ¥å4 allele and structural changes in several hippocampal subfields. The volume reduction in cornus ammonis 1 (CA1) field and subiculum, especially in the APOE ¥å4 carriers. The significance was more prominent in ADconv group.
Conclusion£ºThese results suggest that the possession of APOE ¥å4 allele may lead to significantly greater predilection for the structural changes in hippocampal subfields, showing significant changes, especially in the ADconv patients compared with MCIcont patients.
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KEYWORD
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Early-onset, Mild cognitive impairment, Hippocampus, APOE ¥å4, Atrophy
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